Thakshila Udayakanthi is an analytical chemist. Thakshila graduated with her B. Sc. with honors from the Institute of Chemistry Ceylon in 2011. In 2012, Thakshila moved to the United States to pursue an M. Sc. in chemistry from Ball State University, which she completed Cum Laude in 2014. Her interests have led her to continue this path and she is currently enrolled in her Ph. D. in chemistry at Purdue University.
IUPUI (Purdue University)
Doctor of Philosophy (Ph.D.), and Graduate Assistant at School of Science, 2014-2019
College of chemical science Institute of Chemistry
Bachelor’s degree, Chemistry, 2006 – 2010
UV-vis and Photoluminescence Spectroscopy
Raman Spectroscopy and Surface-Enhanced Raman Spectroscopy
Energy Dispersive and X-Ray Diffraction Spectroscopy
NMR (1H and 13C) and Fourier-Transform Infrared Spectroscopy
Electrospray Ionization Mass Spectrometry
Matrix-Assisted Laser Desorption Ionization/Laser Desorption Ionization-Mass Spectrometry
Gas Chromatography and Liquid Chromatography-Mass Spectrometry
Scanning Electron Microscopy;
IUPUI (Purdue University)
Graduate Assistant at School of Science, 2014-2019
- Developed biological sensors using Localized plasmon resonance property of the metal nanoparticles;
Metallic nanoparticles (Gold, silver) shows a very special property known as Localized Surface Plasmon Resonance (LSPR) which is sensitive to the shape and size of the nanoparticles. In recent years, the LSPR sensors have been widely utilized for the label-free detection of biomolecules across medical, biotechnology fields. Here in my research work mainly utilize the LSPR property of gold triangular nanoprisms for the development of highly sensitive, highly specific multiplexed and high throughput analysis of biomarker related with different diseases including different type of cancers, Cardiovascular disease etc.
- Investigation of Surface Chemistry effects of LSPR property of metallic nanostructures.
Herein, we investigate the spectroscopic investigation of reversible charge delocalization at the inorganic-organic hybrid nanoplasmonic interface by utilizing localized plasmon resonance (LSPR) properties of metal nanostructures. we investigated reversible charge delocalization at the nanostructure-organic ligand interface and further utilized the understanding of this delocalized mechanism to improve the sensitivity of developed sensors to an unprecedented level.
- Developed molecular sensor using Surface Enhanced Raman Spectroscopy.
Surface-enhanced Raman spectroscopy (SERS) is one of the most commonly used techniques for explosive detection. Here we developed a highly sensitive, SERS based, selfassembled, flexible sensor for explosive detection by utilizing the strong electromagnetic enhancement of gold triangular nanoprisms. Our sensor is capable of detecting explosives.
- Manipulate molecular interactions and substrate properties to obtain the evaporative Self-Assembly of metallic nanostructures.
Molecular interactions can be tailored and used to create ordered assemblies. Herein, a simple and efficient evaporative self-assembly method is reported using polyethylene glycol (PEG) functionalized triangular nanoprisms Further, effect of the PEG chain length and the properties of the substrate investigated for an efficient self-assembly process. Further, we have been utilized the developed 3-D self-assembled nanostructure as sensors for the highly efficient and accurate surface enhanced Raman spectroscopy (SERS) substrates for drug screening in plasma obtained from the emergency department.
Ball State Univeristy (Purdue University)
Graduate Research Assistant at Department of Chemistry, 2012-2014
One pot cascade approach to unique phenatharadine –fused quinazoliniminiums from heteroenyne-allenes”, In this project we have demonstrated a concise, facile and a versatile protocol for the Construction of a novel class of heterocycles, namely the phenanthridine-fused quinazolinimines from heteroenyne-allene via SnCl4 or BF3.OEt2 mediated cascade intra-molecular cyclization. The reaction conditions are compatible with most of the tested functional groups and effectively afford the desired product in moderate to excellent yields. Currently we are working on evaluation of biological electrochemical photochemical properties of synthesized compounds.